Cape Ivy is the only species in the plant genus from the family . This promotes the possibility of biocontrol methods that would not harm native vegetation, even species within the family.
Investigations in South Africa have uncovered a moth ( ) and a fly ( ) that damage Cape Ivy in the native region but to do damage other plants, native or non-native. The Cape Ivy moth causes significant damage to Cape Ivy through leaf- and stem-mining. Studies on the moth revealed that the moth only laid eggs on Cape Ivy and was effective for both morphological varieties (stipulate and ) that exist in North America through the reduction in plant growth and biomass accumulation. Applications for release of the moth as a biological control method have been approved by the USDA-APHIS Technical Advisory Group on Biological Control of Weeds.